Isotretinoin review - live consult LIVE real · 2025 no reading time
You are the dermatology registrar in a general dermatology clinic at a metropolitan teaching hospital in New South Wales. It is the Thursday afternoon systemic therapy review clinic. Your consultant is running the adjoining room and has asked you to see the next four patients and to bring anything you are unsure about through to her. A final-year medical student is sitting in with you for the afternoon.
The patient is a 22-year-old woman in the third year of a nursing degree, referred by her GP five months ago. Since the age of sixteen she has developed multiple firm, skin-coloured dermal cysts across the chest, upper arms, axillae and thighs - more than forty at the last count. Over the past two years around a dozen have become inflamed, discharged an oily fluid and healed with depressed scars. An excisional biopsy showed a cyst wall of flattened stratified squamous epithelium with no granular layer, an undulating eosinophilic cuticle, and sebaceous lobules within the wall, confirming steatocystoma multiplex. Her father and a paternal aunt have the same lumps. Her nails, teeth and palms are normal.
She had three months of doxycycline 100 mg daily with no change, and two lesions incised and drained in ED last summer. Six weeks ago she was commenced on isotretinoin 20 mg daily; she weighed 61 kg. Steatocystoma is not a PBS indication, so the script is private and costs her about $70 a month. She was counselled about teratogenicity, asked to use two forms of contraception and to attend for monthly pregnancy testing. Baseline bloods were normal. At her four-week telephone review with the clinic nurse she said the tablets had made no difference and asked whether there was any point continuing. She has rescheduled today's appointment twice by email.
Today's file contains a nursing note from this afternoon recording her weight as 55 kg; bloods taken three days ago showing an ALT of 74 U/L against a baseline of 21, fasting triglycerides of 3.2 mmol/L against a baseline of 1.1, and a normal full blood count and renal function; and a negative pregnancy test this morning. Her medication list still carries fluoxetine 20 mg daily, annotated ‘ceased February at patient's request’ after two years on it, alongside the isotretinoin and a combined oral contraceptive pill. The dispensing history from her pharmacy shows the isotretinoin collected on time both months and the contraceptive pill last dispensed in March.
The clinic's isotretinoin review sheet, which you complete at every visit, has fields for cheilitis, xerosis, epistaxis, myalgia, headache, visual disturbance, pregnancy test, ALT, fasting lipids and the number of inflamed cysts. The hospital pharmacist has left a note on the front of the file asking whether the dose should be increased to 40 mg given the lack of response. Her mother telephoned the clinic yesterday, said she was worried about her daughter, and asked to be rung back after today's appointment.
She has come alone and is in the waiting room. Your consultant puts her head round the door, says she has seen the pharmacist's note, and asks you what you are going to cover in the ten minutes you have, and in what order.
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